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J Control Release 1995; 33: 299–305. 46. Norle´n L, Engblom J. Structure-related aspects on water diffusivity in fatty acid– soap and skin model systems. J Control Release 2000; 63:213–226. 47. Oba N, Sugimura H, Umehara Y, Yoshida M, Kumira T, Yamaguchi T. Evaluation of an oleic acid-water-in-oil-water-type multiple emulsion as potential drug carrier via the enteral route. Lipids 27:701–705. 48. Wick R, Walde P, Luisi PL. Light microscopic investigations of the autocatalytic self-reproduction of giant vesicles.

10. Ishii F, Takamura A, Noro S. Observation of liposomes by scanning electron microscope. Membrane 1982; 7:307–308. 11. Chiou J, Krishna PR, Kamaya H, Ueda I. Alcohols dehydrate lipid membranes: an infrared study on hydrogen bonding. Biochim Biophys Acta 1992; 1110: 225–233. 12. Rottenberg H. Probing the interactions of alcohols with biological membranes with the fluorescent probe Prodan. Biochemistry 1992; 31:9473–9481. 13. Rowe ES. Thermodynamic reversibility of phase transitions. Specific effects of alcohols on phosphatidylcholines.

Based on our work, it is found that both hydrophilic and hydrophobic species can be simultaneously dissolved in TBA/water cosolvent system with an appropriate volume ratio to form an optically clear monophase solution. Lyophilization of the resulting monophase solution will obtain a homogenous codispersion of hydrophilic and hydrophobic species. Further treatment of this kind of solid dispersions will result in the formation of liposomes and oil solution formulations. In this chapter, we will mainly discuss two novel technologies developed in our laboratory.

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